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CL4B resins were pelleted at 16,900 g and 4 C for 1 min, and the supernatants were then incubated with 200 l M2 magnetic beads (Sigma-Aldrich, M8823) and immunoprecipitated at 4 C for 16 h

We will continue to monitor the concerns the commenter has raised and may take the commenter's recommendation into consideration in future rulemaking

1,2 The washout period before trying to conceive differs between the two medications, because they clear from the body at different rates: Mounjaro: stop at least 1 month before trying to conceive 2 Wegovy: stop at least 2 months before trying to conceive 1 If you become pregnant while on the medication, stop and contact your prescriber

The value of t 1/2 was calculated as t 1/2 =ln (2/ k )