MARCH was a 26-week, randomized, placebo-controlled (PBO), Phase 3 trial of maralixibat (MRX), an ileal bile acid transporter (IBAT) inhibitor, that achieved its primary and key secondary endpoints of pruritus and sBA reduction for individuals across the broadest range of PFIC types studied
Observational data suggest sharp increases in mortality, AKI, and myocardial injury below DAP thresholds around 4550 mmHg
In a press release announcing RiVives approval, FDA Commissioner Robert Califf stated the regulators commitment to making naloxone accessible and encouraged other manufacturers of these products to discuss potential nonprescription development programs with the FDA
3.3 Co-culture systems Co-culture models in the lung are extensively employed to examine modifications in alveolar-capillary barrier function, mechanisms of viral or particulate infection (epithelial-macrophage culture), epithelial-mesenchymal associations to investigate remodeling of airway operations, and the influence of smooth muscle mast cell interactions on the reconstruction of the airway [42]