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Proteomic support is provided by ex vivo studies of human PACs demonstrating that human acini preserve key physiological properties while developing pancreatitis-relevant stress responses and organellar abnormalities, indicating that several mechanistic features identified in rodents are also detectable in human acinar tissue (96)

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However, in the reperfusion period, its mutual inhibitory interaction with Bcl-2 reduces the function of Bcl-2, which promotes the formation of apoptosome and thereby makes autophagy change from a protective role to a pro-apoptotic one [116]

Tumor-induced tolerance and immune suppression by myeloid derived suppressor cells