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This work was funded by the European Regional Development Fund (ERDF) through COMPETE 2020, Portugal 2020 and by FCT (Fundao para a Cincia e Tecnologia, ([POCI-01-0145-FEDER-030985 and POCI-01-0145-FEDER-031120] and)

More specifically, research shows small peptides under 16 kilodaltons (kDa) primarily leave the injection site through diffusion into blood capillaries, while larger proteins are predominantly absorbed via the lymphatic system

Prior to any procedures, animals were anesthetized using a combination of xylazine (10 mg/kg) and ketamine (90 mg/kg) for up to one hour via the intraperitoneal route