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Alphaadrenergic receptors inhibit pain neurotransmitter release and reduce the excitability of pain-sensing neurons, resulting in analgesic effects [37,40]

A trial with broiler chickens conducted by Raju and Devegowda (2000) showed a bone ash-decreasing effect of AFB1 (300 g/kg), OTA (2 mg/kg), and T-2 toxin (3 mg/kg), fed individually but an incomparable higher effect when fed in combination

Interestingly, there is emerging evidence that TCAs may improve liver fibrosis and reduce portal hypertensive complications, a potential dual benefit that warrants further investigation [55, 56]

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