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The McGill transgenic rat model of Alzheimers disease displays cognitive and motor impairments, changes in anxiety and social behavior, and altered circadian activity

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Convento MB, Pessoa EA, Cruz E, da Gloria MA, Schor N, Borges FT (2017) Calcium oxalate crystals and oxalate induce an epithelial-to-mesenchymal transition in the proximal tubular epithelial cells: contribution to oxalate kidney injury

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p53 activation enhanced DNA repair, genome integrity, and suppressed CCF formation

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The activation of these pathways sets the foundation for systemic inflammation, exacerbating the local injury and potentially harming distant organs such as the brain

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