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Discovery of MD-224 as a First-in-Class, Highly Potent, and Efficacious Proteolysis Targeting Chimera Murine Double Minute 2 Degrader Capable of Achieving Complete and Durable Tumor Regression

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RNA isolation, reverse transcription, and quantitative real-time PCR (qPCR) Total RNA was extracted using Trizol (Invitrogen, Waltham, MA, USA)