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Unlike the self-polymerization approach, requiring high alkalinity and long reaction times, the enzymatic method achieves fast polymerization under mild conditions, which broadens its range of substrates and applications (Magalhes et al., 2022)

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Another study reported that PINK1 phosphorylated MFN2 at Thr111 and Ser442 to induce MFN2 association with parkin and cause ubiquitination and subsequent degradation of MFN2 ( ATP13A2 ATP13A2 encodes the lysosomal multiple transmembrane P5B-type cation-transporting ATPase ATP13A2

The key role of epigenetics in human disease prevention and mitigation