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K.BjedovI.et al (2021)

However, when the intestinal flora is imbalanced or the hosts immune function is compromised, its morphological plasticity enables it to switch from the yeast form to the hyphal form, thereby breaking through the intestinal epithelial barrier and causing local mucosal infections or even systemic invasive diseases (Alonso-Monge et al., 2024)

Early on was observed that the mechanisms protecting xenografts from being rejected involved a rapid increase of HMOX1 expression by the endothelial and smooth muscle cells from mouse cardiac xenografts transplanted into rats (22)