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indicum extract particularly its major flavonoids enhances neuronal differentiation, possibly by activating the neurogenin2 (Ngn2) promoter and altering of C17.2 neural stem cell fate 43

(2022) The lack of contribution of 7-hydroxymitragynine to the antinociceptive effects of mitragynine in mice: a pharmacokinetic and pharmacodynamic study

2012 PLoS One is the primary cognitive enhancement paper

For example, the rat epithelial mucosa tumors of the nose (the other rodent tumor type of human relevance) possess a robust histopathological data set showing a proliferative regenerative repair MOA basis for this nasal cancer response