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ITTs were performed in random-fed mice, early in their light cycle (~0700h0800h) 46

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In SURPASS-4, tirzepatide 5, 10 and 15 mg reduced triglycerides, low-density lipoprotein cholesterol (LDL-C) and total cholesterol, and increased HDL-C, compared with baseline and the active comparator in the high CV risk population (82% on lipid-lowering therapy at baseline, which was continued throughout the study) [11]

The molecular mechanism of the circadian oscillation of gene expression is mediated by the transcription/translation feedback loop (Nader et al., 2010)