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Examples include curcumin (previously mentioned as a DNMT/METTL3 inhibitor), CUDC-101, tinostamustine (EDO-S101), fimepinostat (CUDC-907), domatinostat (4SC-202), and dacinostat (NVP-LAQ824, LAQ824), all of which are involved in various clinical trials

Most miRNAs genes are transcribed primarily by RNA polymerase II (Pol II) into large primary miRNAs (PRImiRNAs), which contain one or several stem ring structures, each consisting of about 70 nucleotides