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(3) materially alter the budgetary impact of entitlements, grants, user fees, or loan programs or the rights and obligations of recipients thereof

Both studies were conducted in accordance with Good Clinical Practice, the Declaration of Helsinki and US Food and Drug Administration/European Medicines Agency guidelines for studies in people with renal or hepatic impairment Consent to Participate/Publish All participants provided written, informed consent

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634 AAK1 inhibitor LX-9211: Junctional protein 2-associated kinase 1 (AAK1) is widely expressed in the brain and spinal cord and is a viable target for the treatment of neuropathic pain, and BMS-986176/LX-9211 is a novel class of bis(iso)aryl ethers that are highly selective, CNS-permeable, and potent AAK1 inhibitors