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Ovarian estrogens play a key role in the management of the reproductive system such as puberty, fertility, and estrous cycle mostly via interaction with nuclear estrogen receptors [7]

Spontaneous urination samples were collected during handling prior to injections on each treatment day and before euthanization

Apart from receptor-mediated targeting, the enhanced permeability and retention (EPR) effect, or increased permeability and retention of nanoparticles, is also an efficient means by which nanoparticles localize in the tumour area because of the peculiarities of its vascularization and lack of efficient lymphatics [300]