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These ROS not only harm cellular structures but also further impair the BBB by degrading tight junction proteins and promote endothelial death (Fernndez et al., 2020)

A 2024 review of clinical studies in severe gram-negative infections reported clinical success rates of approximately 75%80% for fosfomycin combination therapy regimens, even in patients with MDR pathogens ( 5.3 Standardization gap The lack of standardization presents a pervasive challenge

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173,174 PROM2 overexpression is strongly associated with the increased metastatic potential of melanoma, with similar results found in patient-derived xenotransplantation models of RCC and TNBC