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showed that, in mice, thiamine deprivation for 14 days led to different degrees of enzymatic deficiencies when testing for TKT, PDH, and KGDH activities in the cortex and hippocampus (48)

Moreover, variability in study duration, formulation, and outcome assessment complicates cross-study comparisons

Eculizumab (Soliris), used for atypical hemolytic uremic syndrome (aHUS) and paroxysmal nocturnal hemoglobinuria (PNH), may cause drug-induced liver injury (DILI)

However, the study using incremental doses of APAP demonstrated that, although Il-6 was induced and Stat-3 was activated after a moderately toxic dose and a regenerating dose of APAP, activation of Il-6/Stat-3 signaling was even higher and sustained after a severely toxic dose of APAP, in which liver regeneration was impaired