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Expression of Cyp7a1, the rate-limiting enzyme of BA synthesis, was significantly increased by re-feeding similarly in WT/ND mice and Insr P1195L/ +/ND mice, while that in WT/HFD mice was significantly elevated under fasted condition and did not show further increase by re-feeding

and they have not been evaluated or approved by the FDA to diagnose, treat, cure, or prevent any disease

The panel said that the shots should not be given that broadly, and instead recommended boosters for those over 65, for those with risk factors for severe Covid, and those, like health care workers, whose jobs put them at risk of contracting severe disease