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On the 6th day of admission, bronchoscopy revealed a small amount of yellow secretion in both lower lungs

Drug development continues to face marked inefficiencies, with approximately 90% of drug candidates failing to reach approval despite extensive preclinical testing ( in vitro models, although cost-effective and suitable for high-throughput studies, lack the architectural complexity and biochemical microenvironment of human tissues

These transporters can be classified into two distinct subfamilies characterized by their unique operational features: system A, encompassing prominent members SLC38A1(SNAT1) and SLC38A2 (SNAT2), and system N, encompassing transporters like SLC38A3 (SNAT3), and SLC38A5 (SNAT5) [61]

# 5671094, Bio-Rad) were used to separate 20 g of protein in each lane