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Petroni ML, Brodosi L, Marchignoli F, Sasdelli AS, Caraceni P, Marchesini G, Ravaioli F

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383 In patients with major depression and a genetic mutation that causes disruption in homocysteine metabolism, taking a multivitamin-mineral supplement with the metabolized forms of B vitamins reduced homocysteine levels and was more effective than placebo at reducing depression symptoms, resulting in a 42% remission rate after eight weeks