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One significant challenge is the development of resistance to anti-VEGF therapies, which can occur through various mechanisms, including the upregulation of alternative angiogenic pathways, such as angiopoietin-2 (60)

Nancharaiah YV, Dodge C, Venugopalan VP, Narasimhan SV, Francis AJ (2010) Immobilization of Cr(VI) and its reduction to Cr(III) phosphate by granular biofilms comprising a mixture of microbes

Together, the metabolic host cell responses triggered by bacterial pathogens that are determined by the core response genes aim primarily at increasing antimicrobial activities and decreasing metabolic reactions that may provide essential nutrients to the pathogens, thus inhibiting their proliferation (termed nutriprive mechanisms) (Appelberg, However, bacterial pathogens may also trigger infection-promoting metabolic host responses that counteract these latter antimicrobial reactions of the host and provide protection and/or increased nutrient supply to the pathogen

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