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By preserving SAM, NNMT inhibition may restore normal epigenetic control of metabolic gene expression in fat cells

note in Nature Medicine , NNMT inhibition has been shown to enhance energy expenditure and promote fat loss, even without dietary modification (Kraus et al., Nature Medicine )

There is always a risk of potential side effects when taking medication

When NNMT activity is elevated as documented in obese adipose tissue, several cancer types, and aged skeletal muscle intracellular NAD+ availability decreases, SAM availability decreases, and downstream sirtuin activity (particularly SIRT1 and SIRT3) is reduced