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Primary transcripts are cleaved by Drosha to create precursor microRNAs

It is also being investigated in combination with other investigational or approved compounds , such as semaglutide (a GLP-1 receptor agonist), under the name CagriSema

Other orthobiologics such as stem cell therapy or PRP, even newly developed cell editing drugs like Invossa for knee osteoarthritis have robust safety data in humans and ongoing randomized controlled trials to determine their efficacy

Their function is still a mystery, but the process called splicing removes these non-coding regions from the pre-mRNA transcript (Figure 3.4.3)