glutathione synthetase deficiency wiki Inborn errors in the metabolism of | Orphanet Journal of Rare Diseases The involvement of the Stat1/Nrf2

By regulating iron metabolism in the brain and decreasing the accumulation of iron ions, these agents mitigate oxidative stress and neuroinflammation, which are key contributors to neuronal damage (Zou et al., 2024)

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However, for some other agents, such as cyclophosphamide or methotrexate, the likelihood of inducing CINP is low, and only a single case has been reported in the literature [9]

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