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LH: Data curation, Formal Analysis, Investigation, Software, Validation, Writing original draft

Thus, both lithium and memantine may represent potential therapy against cognitive impairment and Ab1-42-induced neuroinflammation, suggesting their combination could be a promising alternative in treating Alzheimer's disease-like dementias [20]

Circadian clock and immunity Almost all the components of the immune system, involved in adaptive and innate immunity, have been observed to exhibit circadian variations (for a comprehensive review on the topic see 50,51 For example, rhythmic oscillations occur in the trafficking of hematopoietic stem cells and leukocytes, in the expression of recognition receptors and their downstream signaling pathways, and finally in the production of cytokines and chemokines