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Nonetheless, as we shall see, even when tinnitus is triggered by repeated loud noise exposure, ototoxic drugs, some age-related phenomena, or inherited disorders, the subcellular alterations recapitulate those occurring during degenerative tinnitus, and there is a remarkable overlapping between the molecular pathways being affected

Back to Whipple Minot and Murphy, whose importance in this story should not be underestimated, although I applaud them only for their contribution to science in relation to Pernicious Anaemia

However, when the cellular production of ROS/RNS exceeds the intrinsic antioxidant capacity, oxidative stress occurs, which causes damage to intracellular and extracellular biomolecules, resulting in tissue degeneration [20]

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