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doi: 10.1016/j.tibs.2018.05.003 13 NakamuraESatoMYangHMiyagawaFHarasakiMTomitaKet al

Pharmacologic treatments mainly include disease-modifying antirheumatic drugs, nonsteroidal anti-inflammatory drugs, glucocorticoids, biologics, and herbal medicines [10]

Many pharmaceuticals are lipophilic, enabling the drug to diffuse across cell membranes, such as those of the intestinal mucosa or of the target tissue