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[40] With the knowledge of the dopaminergic stimulant effects of the adamantane derivatives, bromantane, which is 2-(4-bromophenylamino) adamantane, was developed in the 1980s at the Zakusov State Institute of Pharmacology, USSR Academy of Medical Sciences (now the Russian Academy of Medical Sciences) in Moscow as "a drug having psychoactivating and adaptogen properties under complicated conditions (hypoxia, high environmental temperature, physical overfatigue, emotional stress, etc.)"

These findings give the AMPK axis firmer translational relevance in thyroid autoimmunity than many upstream targets that are still grounded mainly in non-thyroid autoimmune models

PLoS ONE 10(5):e0126599