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S2CID 1556558

Additionally, several other genes were identified as being implicated in this process, including metal-regulated transcription factor 1 (MTF1), glutaminase (GLS), cyclin-dependent kinase inhibitor 2A, HSP70, dihydrolipoamide branched-chain transacylase E2, SLC31A1, ATOX1, copper chaperone for cytochrome c oxidase 11, dihydrolipoamide S-succinyltransferase and transporters of copper and zinc 1 (ZnT1) (50-54)

To corroborate these findings on a functional level, we isolated activated ILC2s from IL-33 challenged BALB/c mice ( Figure 3A ), which were then incubated for 24h with either an MT1 agonist (Ramelteon), MT1 antagonist (S-26131), MT2 agonist (Tasimelteon), MT2 antagonist (4-P-PDOT) and/or melatonin ( Figures 3BE )

The phenotypic switch from M1 to reparative macrophages (M2) is critical for tissue regeneration (Finley et al., 2016