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Effect of cannabis in combination with antidepressant drugs The immobility time in mice co-administered with fluoxetine (20 mg/kg, s.c.) and cannabis (5 mg/kg, s.c.) was significantly increased compared with the vehicle control group as well as with the cannabis only-treated group

Results TDP-43 is SUMOylated in the nucleus in a context specific manner Various acute stressors including oxidative (sodium arsenite, NaAsO 2 ), hyperosmotic (D-sorbitol and sodium chloride), and heat shock have been demonstrated to induce TDP-43 mislocalization and aggregation in vitro , helping to uncover key mechanisms affected in disease[24, 58, 59]

Weight loss in early stage of Huntingtons disease