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A significant increase in PGRN levels has been reported in the brain and serum of sortilin knockout (KO) mice [104, 105]

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10.1016/j.schres.2017.04.017 393 SetonK

Nivolumab plus ipilimumab as first-line treatment for advanced non-small cell lung cancer (CheckMate 012): results of an open-label, phase 1, multicohort study