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Hydrocodone Withdrawal Timeline Clinicians assess withdrawal severity using the Clinical Opiate Withdrawal Scale (COWS), an 11-item instrument scoring pulse rate, diaphoresis, restlessness, pupil size, bone and joint aches, rhinorrhea, GI upset, tremor, yawning, anxiety, and piloerection on a 0 to 47 scale

The physical symptoms can have a slow onset, a rapid onset, and in some cases, may not appear for long periods of time (remission) (3)

Polybromo-associated BRG1-associated factor components BRD7 and BAF180 are critical regulators of p53 required for induction of replicative senescence