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While challenges in translating findings from animal models to human patients due to differences in important factors such as IVD size, cell turnover, and biomechanical load need to be acknowledged and carefully considered, the usefulness of these experimental models cannot be ignored

Mechanistically, intra-articular AOD-9604 may stimulate synovial fibroblast proliferation or reduce inflammatory cytokine production in the synovial microenvironment, though direct effects on cartilage are unclear

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Understanding its central role (amongst many things) in the Krebs cycle particular wrt to succinly CoA and energy production explains why so many people feel better after injection