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demonstrated that the antiallodynic and antihyperalgesic effects of zerumbone, administered at 10 mg/kg via intraperitoneal injection in the chronic constriction injury (CCI) model, are primarily mediated through the L-arginine-NO/cGMP/PKG/K ATP channel pathways (Zulazmi et al., 2017)

Palmitoyl tetrapeptide-20 promotes hair pigmentation and delays hair graying by activating the MC1-R pathway ( AC 50 : 0.16 nM), enhancing catalase activity to reduce H 2 O 2 accumulation, and upregulating SIRT1 activity

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