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528,529 Metformin, a traditional diabetes drug, upregulated the expression of mitophagy genes, such as PINK , Parkin , and Mfn2 , while at the same time effectively reducing damaged mitochondria after administration, indicating a great potential of metformin as a mitophagy activator

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To accurately dissect the effects of accumulation of fumarate in early phases of epithelial transformation, we silenced FH in non-immortalized non-transformed cells