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First of all, the assessment of treatment efficacy in these studies are limited to the a reduction of senescent cell count as indicated by single markers such as p16 and SA--gal which, as mentioned earlier in this review, may not be an accurate representation of the exact populations targeted by the senolytic CAR-T

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In the second test, they grew hamster cells in the laboratory and treated them with AOD9604, then examined the chromosomes under a microscope to see if any were broken or rearranged