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P = 0.002) and ALT (linear

Circ Res 92: 11931200, 2003

2024;42: e4014

Phenotypic changes also include improved metabolic function in high fat dies mice, reduced atherosclerotic lesion in ApoE -/- mice, enhanced physical function in middle-aged mice, and improved survival in Zmpste24 -/- progeroid mice