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How HIF activity impacts T cell activation and differentiation is a timely topic because it is now also thought that changes in metabolic activity not only accompany the dramatic expansion and acquisition of effector function driven by recognition of antigen, but may also be intimately involved in fate decisions of differentiating effector cells

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Interaction between the PPAR pathway and the enzymes CYP4A and CYP2E1 has been described (Ip et al

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