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Introduction The global incidence of kidney cancer was estimated to increase by approximately 29, 000 cases compared with 2022, accounting for nearly 166, 000 deaths worldwide, an increase of about 10, 000 deaths relative to 2022 ( Although these combinations are associated with maintenance or improvement in health-related quality of life (HrQL) compared to sunitinib monotherapy, treatment-related adverse events (AEs) remain common and treatment-related mortality is not negligible ( However, overlapping toxicities pose a significant challenge for cancer care providers