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doi: 10.1016/j.molcel.2020.10.010 15 CaoZZhaoSHuSWuTSunFShiLI

Metabolic acidosis also enhances branched-chain amino acid dehydrogenase (BCKD) activity and accelerates protein breakdown

Hepatology 60:13361345

To investigate a clinical relevance of the lactic acid-responsive G6PD Y249/322 Tyr phosphorylation and G6PD-SRC-GSTP1 complex, and to establish their potential correlation with breast cancer types, we obtained 13 human breast cancer (T) samples along with adjacent tissues (N) characterized to be normal, and made lysate for detailed IP analyses (Fig