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Contraception 76 , 451455 (2007)

To understand why shedding happens, it helps to look at the hair growth cycle

The administration of HMGB1 substantially increased proliferation, migration, collagen secretion, and expression of -SMA, with noteworthy findings indicating that the HMGB1/IL-1 complex significantly elevated the expression and secretion of critical regulatory factors, including TGF-1, MMP-9, and VEGF (263)