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In the presence of oxidative stress or specific electrophilic stimuli , critical cysteine residues on KEAP1 undergo modifications that disrupt KEAP1-mediated repression, resulting in the stabilization and release of Nrf2

However, when the rats were IV injected 120 microg/kg of DSIP prior to being put in hypoxic conditions it was found that the stress-induced decrease in mitochondrial respiratory activity was completely eliminated