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Results: HT1- HLCs showed accumulation of SA, a hallmark of HT1, upon L-tyrosine and homogentisic acid supplementation

MDD treatment has traditionally focused on the elements that mediate signaling by monoamine neurotransmitters targeted by a vast majority of currently approved antidepressants 10

Notably, the PROTACs that have advanced into clinical studies are, in most cases, still based on this small-molecule design paradigm, rather than on macromolecular or biomacromolecular carrier systems

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