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[8] You are experiencing severe or continuous side effects (mentioned above) You continue to feel loss of interest in pleasurable activities or hobbies Your fatigue does not improve Your sleep is disturbed (insomnia, excessive sleeping) You continue to have difficulty concentrating You experience changes in appetite You experience physical aches and pains Because antidepressants alter your brain chemistry, discontinuing them without medical supervision can cause serious symptoms

121 In the beginning, NADPH binds to the enzyme and reduces the flavin (eq 32), which in turn establishes a charge-transfer complex with one of the cysteines of the active site (Cys63), breaking the previous disulfide bond (eq 33)

Further larger-scale studies estimating VO 2max levels alongside the identification of the genotypic profile for the rs660339 variant and possibly additional variants in the UCP2 gene are needed to validate the findings of the current study

doi: 10.1016/j.tox.2023.153506, 204