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Rheobase was determined as minimal current necessary to elicit 1 st AP during ramps

It has been granted Generally Recognized as Safe (GRAS) status by regulatory authorities in many countries

However, the Liver Tox Knowledge Base (LTKB) may provide more insight into adverse drug reactions in DILI research [255] and allow medical professionals to distinguish DILI caused by agents with different latencies, symptoms, mechanisms, and responses [346]