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Furthermore, necroptotic inflammation is also considered an important driving factor for kidney graft failure

4c, we show that treatment with ENDO3 decreased endolysosomal activity, which recapitulated what was observed in Munc13-4-deficient cells 16 , further validating that the ENDO compounds inhibit Munc13-4-mediated endosomal maturation

Tetlow N, Robinson A, Mantle T, Board P

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