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The primary function of TrxR is to reduce thioredoxin, which is used in a variety of processes (184)

doi: 10.3109/10915818609140731

The risk, benefits and limitation of genetic testing should always be discussed with the patient Patients with confirmed LS, or in those where it is highly suspected but testing is unavailable, require colonoscopic surveillance

The activation of PARP induces major neurotoxicity, as evidenced by the extreme protection against brain damage in PARP knockout mice subjected to transient MCA occlusion (up to 80% reduction of infarct volume) (349, 360)