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Although the specific DNA lesions were not identified, the heightened vulnerability of mtDNA was further supported by experiments using isolated mitochondria, where blue light exposure led to a time-dependent increase in ROS production, such as O 2 , 1 O 2 and OH

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[DOI] [PubMed] [Google Scholar] 115.Neufer P.D., Bamman M.M., Muoio D.M., Bouchard C., Cooper D.M., Goodpaster B.H., Booth F.W., Kohrt W.M., Gerszten R.E., Mattson M.P., et al

We also discuss the relevance of kidney function, another confounder that may alter the GH/IGF-I axis in a manner that can replicate findings seen in acromegaly