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For instance, NUBP2 (involved in regulating iron sulfur cluster formation), GPX1 (H 2 O 2 scavenging selenoprotein), TXNRD1 (H 2 O 2 scavenging selenoprotein) and PSTK (a key enzyme in selenocysteine biosynthesis), emerged as essential genes selectively in the CNS ( Figure Sup

Therefore, a comprehensive understanding of these interactive mechanisms holds important scientific significance and clinical value for elucidating clinical heterogeneity across different age groups, developing novel therapeutic strategies targeting neuroinflammation and mitochondrial function, and predicting disease progression