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Interestingly, this inverse relationship between IGF-1 and longevity is not unique to humans

In the brain, NMDA receptors and calcium signaling are responsible for long-term potentiation, which is the increase in synaptic strength in the brain upon stimulation

247 The ER communicates with mitochondria via mitochondria-associated membranes (MAMs), which are also called mitochondriaER contact sites (MERCSs or ERMCSs) (Fig