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doi: 10.1016/j.cell.2017.11.048 36 DodsonMCastro-PortuguezRZhangDD

Paraquat is taken up into dopaminergic terminals by the dopamine transport and organic cation transporter 3 (Rappold et al., 2011), and causes cellular toxicity by oxidative stress through the cellular redox cycling generating superoxide radical by the oxidation of NADPH, which in turn impairs the restauration of GSH levels and thus the activity of several antioxidant systems (Berry et al., 2002

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However, when mitochondrial membranes are depolarized, the dye fails to form red aggregates